“If I have to put somebody on chronic NSAIDs, naproxen might be my first choice,” Dr. Studies suggest that naproxen (Aleve) is less likely than the other NSAIDs to harm the heart. Which NSAID you choose may make a difference. NSAIDs add yet another risk factor into the mix. People with chronic conditions such as rheumatoid arthritis, obesity and diabetes already face higher odds of developing heart problems, as do those with existing risk factors (such as high blood pressure and high cholesterol) or a strong family history of heart disease. When deciding whether to take an NSAID, also consider your existing heart risks. That need may be significant, considering arthritis pain itself can be disabling. But if you plan to take these drugs daily, he suggests that you weigh the risks against your need for arthritis pain relief. “If you’re just taking them intermittently, they’re probably very safe,” he says. Abramson, MD, chair of the Department of Medicine at NYU Langone Medical Center. Should these risks stop you from taking an NSAID for arthritis pain? That depends on how often you take them, says Steven B. Since 2001, several studies – including one from 2011 in BMJ and a 2013 review in The Lancet – have linked long-term, high-dose NSAID use to a greater risk for heart attack, stroke, heart failure and death from cardiovascular disease. In 2004, the very popular selective COX-2 inhibitor Vioxx (rofecoxib) was pulled from the market over concerns about an increased risk of heart attacks and stroke.Ĭonsidering NSAID Risks and Arthritis Pain The newer celecoxib blocks only the COX-2 enzyme, making it is less likely to cause damage to the stomach. Traditional NSAIDs block prostaglandins by inhibiting two enzymes – COX-1, which plays a role in stomach protection, and COX-2, which is responsible for pain and inflammation. They are widely used to treat arthritis because they help relieve pain and reduce inflammation.Īll NSAIDs work by blocking hormone-like substances called prostaglandins, which are involved in pain and inflammation as well as many other bodily functions, including protecting the stomach lining from its own digestive fluids. Evidence has emerged in recent years indicating that non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of heart attacks, strokes and other heart problems. You may be familiar with traditional ones such as ibuprofen (Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren) as well as, the selective COX-2 inhibitor celecoxib (Celebrex).
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